Axis 2 "Immunosuppressive properties of mesenchymal stromal cells (MSCs): mechanisms and clinical applications related to translational research"

Mesenchymal Stromal Cells (MSCs) are cells found in adult tissues that have self-renewal, multipotency, but also immunomodulation properties. In addition to their role of structural support and production of important factors for tissue development, their anti-inflammatory function is crucial. They are used clinically to treat diseases related to excessive activation of the immune system (autoimmune diseases, graft versus host disease or graft rejection...). Their clinical effectiveness is largely based on their immunomodulatory properties.
 
In our team, we have implemented and use precisely calibrated immunoassays to analyze the impact of MSC production parameters on their immunosuppressive properties.
 
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In this context, we are interested for example in the impact of the tissue source and the method of preparation of the MSCs used, the culture (medium composition, appearance of the state of senescence ...) on the immunological properties of the MSCs.
We also analyze the molecular mechanisms in order to be able to control them.
In addition, we qualify clinical-grade MSCs prior to their injection to patients and provide immunological follow-up for patients treated this way.