Immunomonitoring of clinical trials

  1. Diagnostic and prognostic blood biomarkers in lymphoma: the impact of new anti-tumor drugs
  2. Immunosuppressive properties of mesenchymal stem cells: mechanisms and clinical applications
  3. Suppressive meiotic cells and sepsis

Diagnostic and prognostic blood biomarkers in lymphoma: the impact of new anti-tumor drugs

Title / Acronym : BIO-FLIRT
Objective : To compare the efficacy of two therapeutic strategies (rituximab SC vs rituximab IV) in patients with previously untreated low tumor mass follicular lymphoma.
Principal investigators : Guillaume CARTRON (CHRU Montpellier, France), Delphine PRANGER (Great Hospital of Charleroi, Belgium)
Funding : LYSARC / Roche Laboratory
Duration : 5.5 years
Other information : French multicentre phase III trial for which patients are immunomonitored in Rennes
 
Title / Acronym : BIO-GALEN
Objective : For phase Ib, determine the recommended dose of lenalidomide for use in combination with obinutuzumab. For Phase II, measure the efficacy of this combination therapy in patients with follicular lymphoma or diffuse large cell lymphoma
Principal Investigators : Franck Morschhauser (CHRU Lille, France), Roch Houot (CHU Rennes, France)
Funding : LYSARC / Roche and Celgene Laboratories
Duration : 10 years
Other information : Phase Ib / II trial for which all patients are immunomonitored in Rennes
 
Title / Acronym : BIO-LEVEL
Objective : To measure the gain in clinical efficacy provided by the addition of nivolumab to Gemcitabine / Oxaliplatin / Rituximab in patients who are elderly or who are not eligible for high-dose chemotherapy and who have non-Hodgkin's lymphoma in their first relapse.
Principal investigators : Gerald  Held (Germany)
Funding : BMS laboratory
Duration :
Other information : European multicenter phase II / III trial for which French and German patients are immunomonitored at the SITI laboratory

 

Immunosuppressive properties of mesenchymal stem cells: mechanisms and clinical applications

Title / Acronym : FATSCAR
Objective : To evaluate the effect of adipose tissue autograft on a scarred ulcer on pressure ulcer recurrence
Principal Investigators : Cécile Méal under the responsibility of Nicolas Berteuil (CHU Rennes, France)
Funding : Rennes University Hospital (CORECT 2017 program)
Duration : 1 year
Other information :
 
Title / Acronym : Mechanical-SVF
Objective : Characterization of stromal vascular fraction (SVF) derived from adipose tissue obtained by mechanical dissociation and comparison with enzymatic digestion
Principal investigators : Nicolas Berteuil (CHU Rennes, France)
Funding : Rennes University Hospital (CORECT 2017 program)
Duration : 1 year

Other information : Study carried out at Rennes University Hospital on 15 subjects
 
Title / Acronym : ADIPOA-2
Objective : To ensure the safety and tolerability of treatment of osteoarthritis by injection of adipocyte stem cells into the knee joint in order to repair cartilage damaged by the disease and to relieve pain.
Principal Investigators : Christian Jorgensen (CHU Montpellier, France)
Funding : European Union
Duration : 2 years
Other information : partner clinical centers in 6 countries (France, Ireland, Italy, Germany, the Netherlands, United Kingdom) with immunomonitoring of the French, Italian and german patients in 2 sites (Rennes and Montpellier)
 
Title / Acronym : Scleroderma
Objective : To analyze the immunomodulatory and anti-fibrotic effects of bone marrow-derived allogeneic mesenchymal stem cell (MSC) injection by analyzing systemic and cutaneous responses in patients with systemic scleroderma.
Principal Investigators : Dominique Farge
Funding : APHP / eCellFrance
Duration :
Other information : Phase I-II trial in one center (Paris) for 12 patients in phase I-II who are immuno-monitored in Rennes at the SITI laboratory

 

Suppressive meiotic cells and sepsis

Title / Acronym : Imprim
Objective : To study immunodeficiency biomarkers in all ICU patients, comparing non-septic patients to septic patients. Achieving this objective will make it possible to study the prevalence of immunodepression acquired during intensive care, and to identify early and objectively the patients most at risk of developing nosocomial infections.
Principal Investigators : Fabrice UHEL (CHU Rennes, France)
Funding : Rennes University Hospital (CORECT 2015 program)
Duration : 24 months
Other information : Monocentric
 
Title / Acronym : Randomized L-Citrulline Immuno nutrition Trial in Medical Resuscitation / Immunocitre

Objective : To study the effects of citrulline administration on immune dysfunction acquired during resuscitation. The main objective is to show that in patients with medical resuscitation with hypo-arginine on admission, the group of patients receiving L-citrulline, compared to the group receiving iso-nitrogenized placebo, has a organ failure decreased on day 7 (evaluated by the SOFA score).
Principal investigators : Jean-Marc Tadié (CHU Rennes, France)
Funding : Hospital Interregional Clinical Research Program 2014
Duration : 24 months
Other information : This is a prospecting study

Title / Acronym : Immunological and bacteriological approaches of the development of postoperative mediastinitis due to Staphylococcus aureus / Mediastaph
Objective : To demonstrate that the increase in plasma activity of the Indoleamine 2,3-dioxygenase enzyme (IDO) is responsible for hypo-reactivity of neutrophils (PNN) and macrophages during exposure to Meticillin-sensitive Staphylococcus aureus (SAMS). The specific inhibition of IDO could thus allow a restoration of the phagocytosis and bactericidal capacities.
Principal investigators : Jean-Marc Tadié
Funding : 2014-2016 Foundation of the Future
Duration : 24 months
Other information : Monocentric
 
Title / Acronym : Study of the effects of bronchoalveolar lavage fluids in the ARDS on the functioning of the polynuclear neutrophils / BALARDS

Objective : i) To demonstrate that the AML liquid from ARDS patients causes delayed PNN apoptosis, ii) To demonstrate that BAL fluid causes a decrease in apoptotic PNF efferocytosis by macrophages and PNN (measurement of phagocytic index).
Principal investigators : Murielle Grégoire / Jean-Marc Tadié
Funding : CORECT 2015 (CHU Rennes)
Duration : 24 months
Other information : Monocentric
 
Title / Acronym : Beneficial effects on cardiopulmonary by cardiac surgery on postoperative infections / VECAR

Objective : to demonstrate that the maintenance of mechanical ventilation during CPB significantly reduces the frequency of postoperative infections. This is why we believe that the intraoperative management of patients could limit postoperative immunodepression.
Principal investigators : Jean-Marc Tadié
Funding : National Hospital Clinical Research Program (881 881 euros)
Duration : 24 months
Other information : Multicenter study. 1400 patients including 500 patients with immunomonitoring performed in Rennes